
In Memoriam
Jackie Fox: Executive Director of the Council for Homeopathic Certification (CHC)
It is with great sadness that we have to say goodbye to Jackie Fox who died recently at home, surrounded by her family. Jackie had been the backbone of the CHC for over ten years and had quietly, but assiduously given direction to the organization as it continued to grow and evolve. She brought a calm and sympathetic energy to her work and in the sometimes fraught times dealing with the complex issues of certification, she was able to reassure candidates as they went through all the steps towards certification.

Editorial
by Richard Pitt
Scientific research is a significant cornerstone of our understanding of the human body and of life itself. In the last 200 years it has become ever more important in our developing knowledge of how things work. What used to be known simply through empiricism, experience, belief/faith and through an intuitive, yet profound connection to the world around us, we now rely on more academic, abstract analyses of the nature of things and our interaction to the world. This very much includes medical research and how the body works and how medicines can be found to be effective and ideally safe.
Homeopathy, as one system of medicine, has also embarked on research to validate the experience of its theoretical principles and to explain the experience of the millions who benefit from homeopathy. It is also important as a means to communicate to other medical researchers and practitioners how homeopathy works and what conditions it is more likely to work on. For practitioners of homeopathy, it is another way to validate what we know to be true through our own experience. Homeopathy works.

Guest Editorial: Scientific Research of Homeopathy
by Kathleen Scheible
I am very excited about the range of global scientific research being conducted on homeopathy. I’m happy to co-edit this edition for the California Homeopath, and bring some of this research to you. We have featured an array of topics including: groundbreaking characterization of the nature of the remedies; hypothesis of mechanism of action; positive RCT double blind placebo controlled studies; challenges with the current scientific paradigm in studying homeopathy; and adoption of homeopathy in a public health setting based on cost-effectiveness and efficacy. This edition brings you up to date on the scientific study of homeopathy.

An Overview of Positive Homeopathy Research and Surveys
An Overview of Positive Homeopathy Research and Surveys
The European Network of Homeopathy Researchers
March 2007
This document has been produced by the European Network for Homeopathy Researchers (ENHR).
The ENHR was established in 2004 with support from the European Council for Classical
Homeopathy (ECCH). ECCH currently assists the ENHR in its secretarial work. The ENHR consists
of 66 individuals from 15 different countries involved in or with a special interest in homeopathy
research. The ENHR is open to membership for any individual involved or interested in homeopathy research.

A Review of Basic Research on Homeopathy by a Physicist
Volume 19 Issue 1
Author: Papiya Nandy
ABSTRACT
Homoeopathic medicine has been one of the world’s most widely practiced alternative therapies. However, that the potency of a homoeopathic medicine increases with dilution followed by succussion (together termed as potentization) has thrown challenges to the scientific community at large. A recent hypothesis, advanced by us and others, is that due to the process of potentization, the size of the constituent particles decreases and eventually reaches nanodimension. This decrease in size with increase in potency has been verified by scanning electron microscopy and dynamic light scattering studies.
The increase in potency is manifested in its increased effect on membrane fluidity. The change in potency also leaves its signature on Ultraviolet–Visible spectra, Fourier transform infrared radiation spectra and Raman spectra. We have taken one step further to carry this nano‑dimensional property of homoeopathic medicine and put it into several technical applications. And in so doing, we have connected the important, old, un‑quantifiable effects with the latest quantifiable technology and opened up an era of applications with more possibilities.
Keywords: Anisotropy, Characterization, Homoeopathy, Nanomedicine, Nano‑technology, Potentization

Homeopathia! Quo Vadis? 2nd Homeopathic Research Institute International Conference
By Lionel Migrom
An overview of homeopathic research and the Homeopathic Research Institute (HRI) conference in June 2015

In the Pursuit of Evidence
by Kate Chatfield
This paper was first published in 2007, at a time when homeopathy in the UK was receiving a considerable amount of adverse publicity. Unfortunately, the situation is not greatly improved and currently homeopaths in many other countries around the world are facing a similar challenge. Repeatedly, critics ask the same question: “Where is your evidence?” Consideration of this question led me to become involved with homeopathy research many years ago, but increasingly I found that my background in philosophy compelled me to challenge the very concepts of evidence, proof and science that were driving the research agenda. What follows is an account of evidence-based medicine, some of the implications for homeopathy, and philosophical challenges for the foundations of our assumptions. It has been modified slightly from the original 2007 paper in the light of subsequent developments.

“Living is easy with eyes closed ...” on blinded RCTs and specific andnon-specific effects of complex therapeutic interventions!
By Lionel Milgrom
Abstract
Introduction: It is assumed that, as measured during randomised placebo-controlled trials, specific and non-specific effects of an intervention do
not interact with each other, and are simultaneously observable. It is argued this assumption means the results of RCTs (particularly for complex
interventions, such as homoeopathy) are treated too simplistically.
Purpose of study: To examine if a complex intervention’s specific effects and non-specific effects are complementary (in a sense derived and
generalised from quantum theory), i.e., correlated sets of observables from an RCT, in which both are necessary to achieve a more complete
understanding of the efficacy of an intervention.
Methods: Building on earlier work, and based on the properties of Abelian and non-Abelian algebras, a mathematical argument is developed,
which is used to examine the nature of the relationship between a complex intervention’s specific effects and non-specific effects as observables
from RCTs.
Results: The mathematical argument suggests that it is essentially incorrect to assume specific effects and non-specific effects of a complex
intervention (as measured during an RCT of a complex intervention) can be separated into simultaneously measurable, non-interacting sets of
observables.
Conclusion: This calls into question not only the legitimacy of conclusions drawn from RCTs, but also the blinded observational stance of the
RCT protocol (which currently justifies – and is justified by – a reductionist approach to the efficacy of complex therapeutic interventions). Indeed,
such RCTs might well be demonstrating a Heisenberg-type uncertainty between the specific effects of the intervention and the non-specific effects
of the consultation, as complementary observable parts making up a whole irreducible phenomenon: the therapeutic process.
© 2014 Elsevier GmbH. All rights reserved.
Keywords: Evidence-based medicine; RCTs; Specific and non-specific effects; Complex interventions; Abelian and non-Abelian algebras; Quantum theory

Solving the Homeopathic Puzzle One Step at a time: Adaptive Network Nanomedicine
by Iris R. Bell, MD PhD
What is a homeopathic remedy? What is a homeopathic potency? How does a remedy act?
Those questions have fascinated proponents of homeopathy and mobilized the doubts of skeptics for over two centuries. In recent years, various researchers have finally begun to discover important scientific clues to answer these questions. Do we have the final answers? Not yet, but we do have valuable new insights and advances. In our research group, we have summarized our understanding of the available scientific evidence into what we call the “adaptive network nanomedicine” model for homeopathy.

Nanoparticle Characterization of Traditional Homeopathically Manufactured Gelsemium Sempervirens
Bell IR1-3*, Muralidharan S4, and Schwartz GE5
1Department of Family and Community Medicine, The University of Arizona College of Medicine, AZ, USA
2College of Nursing, The University of Arizona, Tucson, AZ, USA
3The American Medical College of Homeopathy, Phoenix, AZ, USA
4Department of Molecular and Cellular Biology, University of California Davis, CA, USA
5Department of Psychology, The University of Arizona, Tucson, AZ, USA
Abstract
Multiple studies have observed nanostructures in traditionally-manufactured homeopathic medicines.
Homeopathy is a 200-year-old system of complementary and alternative medicine used worldwide. The nature of homeopathic medicines has historically stimulated much debate. The present placebo-controlled study extended previous work to characterize nanoparticles (NPs) in homeopathically-prepared Gelsemium sempervirens (GELS), a natural botanical source with previously-documented anxiolytic, analgesic, and anticancer properties. An ethanolic GELS herbal extract was serially diluted and succussed (agitated) in a 95% ethanol-water diluent solvent in glass vials, following Homeopathic Pharmacopoeia of the U.S. guidelines. GELS (VERUM, at homeopathic potencies of 6C, 30C, 200C, each n=3 vials), succussed controls (SUCC-CONT, at homeopathic potencies of 6C, 30C, 200C, each n=3), and one set of unsuccussed solvent control vials also used natural cork (Quercus suber) stoppers (UNSUCC-cork, n=3). A final set of unsuccussed solvent controls used silicone stoppers (UNSUCC- silicone, n=3). Analytical methods included nanoparticle tracking analysis (NTA), zeta potentials, and UV-Visible spectroscopy. NTA revealed >4 x 108 nanoparticles per milliliter in all VERUM, SUCC-CONT, and UNSUCC-cork vials, significantly more than the UNSUCC-silicone controls. Particle sizes were polydisperse, significantly larger in the VERUM 30C at 129.8 nanometers versus SUCC-CONT at 6C, 30C, 200C and the UNSUCC-cork controls.
Zeta potentials consistent with greater particle stability were significantly most negative in the VERUM GELS 200C (-47.75 mV). Within the UV-vis wavelength range 300-400 nm, the SUCC-CONT 30C exhibited significantly higher, whereas UNSUCC-silicone stopper controls had significantly lower, mean absorbance than all other samples.
Taken together, the data suggest that traditional homeopathic methods involving succussions release not only the previously-shown silica from glassware walls, but also Quercus suber materials from natural cork stoppers to stabilize NPs in solution. With verum source material Gelsemium, additional NP size growth and surface stabilization can occur. Further study of homeopathic manufacturing materials and methods and their biological correlates is indicated.
Keywords: Nanoparticles; Gelsemium sempervirens; Silica; Quercus suber; Homeopathy; Nanoparticle tracking analysis; Zeta potential

The Swiss Government’s Remarkable Report on Homeopathic Medicine
by Dana Ullman, Evidence Based Homeopath
The Swiss government has a long and widely-respected history of neutrality, and therefore, reports from this government on controversial subjects need to be taken more seriously than other reports from countries that are more strongly influenced by present economic and political constituencies. When one considers that two of the top five largest drug companies in the world have their headquarters in Switzerland, one might assume that this country would have a heavy interest in and bias toward conventional medicine, but such assumptions would be wrong.
In late 2011, the Swiss government’s report on homeopathic medicine represents the most comprehensive evaluation of homeopathic medicine ever written by a government and was just published in book form in English (Bornhoft and Matthiessen, 2011). This breakthrough report affirmed that homeopathic treatment is both effective and cost-effective and that homeopathic treatment should be reimbursed by Switzerland’s national health insurance program.